The Live Ahmedabad
  • Home
  • Ahd City
  • Business
  • Entertainment
  • Education
  • Crime
  • Health
  • Politics
  • Sports
  • Featured

The Live Ahmedabad

  • Home
  • Ahd City
  • Business
  • Entertainment
  • Education
  • Crime
  • Health
  • Politics
  • Sports
  • Featured
Nation

New nano-formulation may help bring safer treatment for Parkinson’s Patients

by TLAteam January 27, 2025January 27, 2025
written by TLAteam January 27, 2025January 27, 2025
New nano-formulation may help bring safer treatment for Parkinson’s Patients

Researchers have developed a targeted nano formulation that can help sustained release of a hormone called 17β-Estradiol which is crucial for managing Parkinson’s Disease (PD).

Business News

Many neurodegenerative and psychiatric malignancies like Parkinson’ disease (PD) originate from an imbalance of 17β-Estradiol (E2) in the human brain. However, the peripheral side effects of the usage of E2 for PD therapy and less understanding of the molecular mechanism hinder establishing its neurotherapeutic potential.

Scientists from Institute of Nano Science and Technology (INST) Mohali, an autonomous institute of Department of Science and Technology, used Dopamine Receptor D3 (DRD3) conjugated to 17β-Estradiol-loaded chitosan nanoparticles that led to sustained release of 17β-Estradiol (E2) to the brain.  

The targeted nano-formulation inhibited the mitochondrial translocation of calpain, thereby protecting neurons from rotenone-induced mitochondrial damage. Furthermore, the targeted nano delivery system alleviated behavioural impairments in a rodent model. Additionally, the study reveals for the first time that BMI1, a member of the PRC1 complex that regulates mitochondrial homeostasis, is a substrate of calpain. The targeted nano-formulation restored BMI1 expression by inhibiting its degradation through calpain.

The study Carbohydrate Polymers has helped in understanding the role of hormone (E2) in regulating oxidative stress in PD patients. With the continued exploration of long-term safety profiles and better-targeted delivery, this can establish itself as a safer drug to improve the lives of Parkinson’s patients.

0 comment
previous post
2025 to Synchronize Time across India, “One Nation, One Time” in the country
next post
Coldplay Magic: Ahmedabad Metro had highest passengers ever on single day

You may also like

Centre Plans Major GST Relief for Middle Class,...

July 3, 2025

SEBI Opens 6-Month Window for Re-Lodging Old Share...

July 3, 2025

Ramayana Yatra to Begin on July 25, Pilgrims...

July 3, 2025

Water Levels Cross Warning Mark at 11 River...

July 2, 2025

Milind Soman Completes 600-Km Mumbai-Goa Challenge in 5...

July 2, 2025

No Link Between COVID Vaccine and Sudden Deaths,...

July 2, 2025

Govt Clears Bike Taxis, But Rapido, Uber Need...

July 2, 2025

Ola, Uber Get Govt Approval for Surge Pricing;...

July 2, 2025

Sevagram Ashram Trust announces fellowship for studies in...

July 1, 2025

Cabinet Clears ₹1.07 Lakh Crore for Job Creation,...

July 1, 2025

Leave a Comment Cancel Reply

Save my name, email, and website in this browser for the next time I comment.

Business News

Recent Posts

  • Centre Plans Major GST Relief for Middle Class, May Scrap 12% Slab

    July 3, 2025
  • GU to Begin Dual Degree Admissions from July 20

    July 3, 2025
  • Traffic Cops to Collect Fines via QR Codes

    July 3, 2025
  • Shanti Business School conducted Induction Programme

    July 3, 2025
  • St. Xavier’s College Welcomes New Undergraduate Batch

    July 3, 2025
January 2025
MTWTFSS
 12345
6789101112
13141516171819
20212223242526
2728293031 
« Dec Feb »
The Live Ahmedabad
Footer Logo
  • Home
  • Ahd City
  • Business
  • Entertainment
  • Education
  • Crime
  • Health
  • Politics
  • Sports
  • Featured
  • Privacy Policy
  • Disclaimer
  • Cookie Policy
  • Terms of use
  • Advertise with Us
  • Work With Us
  • Contact Us

© 2021 - The Live Ahmedabad. All Rights Reserved.