The Live Ahmedabad
  • Home
  • Ahd City
  • Business
  • Entertainment
  • Education
  • Crime
  • Health
  • Politics
  • Sports
  • Featured

The Live Ahmedabad

  • Home
  • Ahd City
  • Business
  • Entertainment
  • Education
  • Crime
  • Health
  • Politics
  • Sports
  • Featured
Nation

New drug-capsule may one day replace insulin injection for diabetics

by TLAteam July 23, 2023July 23, 2023
written by TLAteam July 23, 2023July 23, 2023
New drug-capsule may one day replace insulin injection for diabetics

Australian scientists have designed a new type of oral capsule that could one day mean pain-free delivery of insulin and other protein drugs.

Business News

Thousands of people with diabetes need insulin injections up to several times a day, which can be unpleasant for the patient and results in high healthcare costs.

According to Dr Jamie Strachan, from RMIT University, the capsule protected the drug inside so that it passed safely through the stomach to the small intestine.

The capsule has a special coating designed to not break down in the low pH environment of the stomach, before the higher pH levels in the small intestine trigger the capsule to dissolve,” said Strachan, from the School of Science.

“We package the insulin inside a fatty nanomaterial within the capsule that helps camouflage the insulin so that it can cross the intestinal walls.

“It’s actually similar to how the Pfizer and the Moderna Covid vaccines work where the mRNA in those vaccines is also packaged within fats, helping to keep the drugs active and safe during delivery in the body.”

These vaccines contain mRNA, which is similar to DNA, to safely carry the instructions for making a viral protein within the body, activating our immune system.

Dr Celine Valery, a pharmaceutical scientist from RMIT and study co-author, said they used the same amount of insulin in the oral capsules and in the injection delivery.

The study, published in the international journal Biomaterials Advances, tested the new oral capsule with insulin in a pre-clinical study, which assessed the performance of the oral capsules with both fast-acting and slow-acting insulin.

“When controlling the blood-sugar, you need a very fast response if you’re eating a meal. That’s known as fast-acting insulin,” said said co-lead researcher Professor Charlotte Conn, a biophysical chemist from RMIT University, from the School of Science.

A slow-acting form acts over a much longer timeframe — up to a day or so — to keep the insulin in the body steady. Most diabetics take a combination of both types of insulin.

“We had excellent absorption results for the slow-acting form — about 50 per cent better than injection delivery for the same quantity of insulin,” Conn said.

The capsule achieved good absorption results for fast-acting insulin, but the significant lag in the insulin taking effect compared with injection delivery would likely make it less practical.

“Our results show there is real promise for using these oral capsules for slow-acting insulin, which diabetics could one day take in addition to having fast-acting insulin injections,” Conn said.

“The oral capsules could potentially be designed to allow dosing over specific time periods, similar to injection delivery. We need to investigate this further, develop a way of doing so and undergo rigorous testing as part of future human trials.”

“It’s a great starting point but we need to do further trials to develop an alternative, pain-free method for the delivery of insulin and other protein drugs.”

The new technology could also be used to deliver orally other protein drugs such as monoclonal antibodies developed to treat inflammatory conditions, cancer and other diseases.

0 comment
previous post
BSIP Lucknow to host INQUA in 2027, first in India
next post
Rakul Preet Singh flaunts her curves in bikini

You may also like

“18 Years. 2 Virgins”: Durex India’s Bold IPL...

June 3, 2025

Nashik Kumbh Mela 2025 Starts on October 31-...

June 3, 2025

Rajeev Shukla Likely to Become BCCI President as...

June 2, 2025

Sensex Falls 700 Points Despite Strong GDP Growth:...

June 2, 2025

New Financial Rules from June 1: EPFO, Aadhaar...

June 1, 2025

COVID-19 Cases Rise in India, Over 3,000 Active;...

June 1, 2025

Indian Tourist Attacked by Tiger in Thailand While...

May 31, 2025

Modi Government Launches ‘1600’ Number Series to Stop...

May 31, 2025

June 2025 Bank Holidays: State-Wise List and Total...

May 31, 2025

WhatsApp to Stop Working on Some Old Phones...

May 31, 2025

Leave a Comment Cancel Reply

Save my name, email, and website in this browser for the next time I comment.

Business News

Recent Posts

  • NBEMS Seeks Supreme Court Nod to Hold NEET PG 2025 on August 3 After Postponement

    June 3, 2025
  • Flipkart to Host Glam Up Fest 2025, Reinforcing Its Position as India’s Go-To Destination for Beauty Commerce and Leadership in K-Beauty

    June 3, 2025
  • “18 Years. 2 Virgins”: Durex India’s Bold IPL 2025 Post Goes Viral Ahead of RCB vs PBKS Final

    June 3, 2025
  • Sachivalaya to Spend ₹110 Crore on AC Upgrade, While Public Services Remain Slow

    June 3, 2025
  • Afreen Alvi Wows in White Bikini

    June 3, 2025
July 2023
MTWTFSS
 12
3456789
10111213141516
17181920212223
24252627282930
31
« Jun Aug »
The Live Ahmedabad
Footer Logo
  • Home
  • Ahd City
  • Business
  • Entertainment
  • Education
  • Crime
  • Health
  • Politics
  • Sports
  • Featured
  • Privacy Policy
  • Disclaimer
  • Cookie Policy
  • Terms of use
  • Advertise with Us
  • Work With Us
  • Contact Us

© 2021 - The Live Ahmedabad. All Rights Reserved.